|
Mammary Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
An association between the matrix metalloproteinase 1 promoter gene polymorphism and lymphnode metastasis in breast cancer.
|
15149160 |
2004 |
|
Mammary Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Both a MMP-1 inhibitor and P1pal-7 significantly promote apoptosis in breast tumor xenografts and inhibit metastasis to the lungs by up to 88%.
|
19622769 |
2009 |
|
Mammary Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material.
|
17669621 |
2008 |
|
Mammary Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The levels of the matrix metalloproteinase MMP1 mRNA in three breast tumour cell lines with varying numbers of epidermal growth factor (EGF) receptors, MDA-MB-231, T47D and MCF7, were investigated following treatment with EGF or TGF alpha in serum-free medium for up to 24 h. A higher level of MMP1 mRNA was found in both control and treated MDA-MB-231 cells compared with the other two cell lines.
|
9014756 |
1996 |
|
Mammary Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_mouse |
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.
|
25330770 |
2014 |
|
Mammary Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
We conclude that MMP-1 expression is essential for the ability of MDA-231 cells to invade and destroy a collagen matrix and in vivo experiments suggest an important role for MMP-1 in breast tumor growth.
|
16322260 |
2005 |
|
Mammary Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses.
|
23548910 |
2013 |
|
Mammary Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors.
|
22011282 |
2011 |
|
Mammary Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Promotion of metastasis in response to miR-224 downregulation was associated with derepression of the stroma-associated RKIP target genes, CXCR4, MMP1, and OPN, which are involved in breast tumor metastasis to the bone.
|
22809510 |
2012 |
|
Mammary Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis.
|
18366705 |
2008 |
|
Mammary Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-1 and MMP-9 in breast cancer.
|
16267613 |
2006 |
|
Mammary Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
High MMP-1 mRNA expression is a risk factor for disease-free and overall survivals in patients with invasive breast carcinoma.
|
17663001 |
2008 |
|
Mammary Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
The 2G single nucleotide polymorphism (SNP) in the MMP-1 promoter contributes to high levels of MMP-1 transcription in MCF-7/ADR breast cancer cells.
|
14692651 |
2003 |
|
Mammary Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Modulation of monocyte matrix metalloproteinase-2 by breast adenocarcinoma cells.
|
16168111 |
2005 |
|
Mammary Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
MMP-1 (interstitial collagenase) has been associated with MDA-MB-231 invasion in vitro, while MMP-3 (stromelysin-1) has been localised around invasive cells of breast tumours in vivo.
|
16430785 |
2006 |
|
Colorectal Neoplasms
|
0.380 |
Biomarker
|
group |
LHGDN |
Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma.
|
17543340 |
2008 |
|
Colorectal Neoplasms
|
0.380 |
GeneticVariation
|
group |
LHGDN |
Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma.
|
17125518 |
2006 |
|
Colorectal Neoplasms
|
0.380 |
GeneticVariation
|
group |
LHGDN |
The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer.
|
17311017 |
2007 |
|
Colorectal Neoplasms
|
0.380 |
Biomarker
|
group |
CTD_human |
Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses.
|
23548910 |
2013 |
|
Colorectal Neoplasms
|
0.380 |
AlteredExpression
|
group |
LHGDN |
Low collagenase-1 (MMP-1) and MT1-MMP expression levels are favourable survival markers in advanced colorectal carcinoma.
|
14707454 |
2003 |
|
Colorectal Neoplasms
|
0.380 |
GeneticVariation
|
group |
LHGDN |
Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.
|
15701845 |
2005 |
|
Colorectal Neoplasms
|
0.380 |
GeneticVariation
|
group |
LHGDN |
The influence of interstitial collagenase-1 genotype polymorphism on colorectal cancer risk in Iranian population.
|
18798060 |
2008 |
|
Colorectal Neoplasms
|
0.380 |
GeneticVariation
|
group |
LHGDN |
Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer.
|
12432557 |
2002 |
|
Colorectal Neoplasms
|
0.380 |
AlteredExpression
|
group |
LHGDN |
Stromal expression of invasion-promoting, matrix-degrading proteases MMP-1 and -9 and the Ets 1 transcription factor in HNPCC carcinomas and sporadic colorectal cancers.
|
12949792 |
2003 |
|
Lung Neoplasms
|
0.370 |
AlteredExpression
|
group |
BEFREE |
Hypoxia-inducible factor-1α, pro-angiogenic protein matrix metalloproteinase 1, and VEGF are all highly expressed in Cr(VI)-transformed cells, in lung tissue from animals exposed to Cr(VI), and in lung tumor tissue from a non-smoking worker occupationally exposed to Cr(VI) for 19 years. p38 MAPK is also activated in Cr(VI)-transformed cells and in human lung tumor tissue.
|
27226640 |
2016 |